Status:
COMPLETED
Renal Denervation in Heart Failure With Preserved Ejection Fraction
Lead Sponsor:
Royal Brompton & Harefield NHS Foundation Trust
Conditions:
Cardiac Failure
Eligibility:
All Genders
18-85 years
Phase:
PHASE2
Brief Summary
The purpose of this study is to determine whether renal sympathetic denervation (RSD)(a treatment that lowers the activity of the sympathetic nervous system) is useful in the management of patients wi...
Detailed Description
Increasing evidence suggests an important role of activation of the sympathetic nervous system (SNS) in heart failure with preserved left ventricular ejection fraction. The current study aims to evalu...
Eligibility Criteria
Inclusion
- EF\>40%
- NHYA 2-3
- Evidence of HF-PEF (mixture of dilated left atrium, left ventricular hypertrophy, raised E/E', elevated LVEDP/PCWP, raised BNP)
Exclusion
- Previously documented EF\<40%
- Hypertrophic, restrictive, dilated cardiomyopathy
- Significant valvular heart disease
- Unfavourable renal artery anatomy for renal denervation
- eGFR\<45
- Contraindication to MRI
- Myocardial infarction, unstable angina or cerebrovascular accident in last 3 months
Key Trial Info
Start Date :
April 1 2013
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
September 1 2015
Estimated Enrollment :
25 Patients enrolled
Trial Details
Trial ID
NCT01840059
Start Date
April 1 2013
End Date
September 1 2015
Last Update
September 15 2015
Active Locations (1)
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1
Royal Brompton Hospital
London, United Kingdom, SW3 6NP