Status:
WITHDRAWN
Sulindac for Patients With AML
Lead Sponsor:
Massachusetts General Hospital
Conditions:
Acute Myeloid Leukemia
Eligibility:
All Genders
60+ years
Phase:
PHASE2
Brief Summary
This research study is a Phase II clinical trial. Phase II clinical trials test the effectiveness of an investigational drug to learn whether the drug is effective in treating a specific cancer. "Inve...
Detailed Description
To determine if you are eligible to participate in this study you will be asked to undergo some screening tests or procedures. Many of these tests and procedures are likely to be part of regular cance...
Eligibility Criteria
Inclusion
- Pathologically confirmed newly diagnosed acute myelogenous leukemia in complete remission following induction chemotherapy
Exclusion
- Plan for consolidative stem cell transplant in CR1 at the time of enrollment
- Previous history of coronary artery disease or heart failure
- Previous history of major allergic reaction to aspirin or other non-steroidal anti-inflammatory drugs
- Previous history of gastric or duodenal ulceration
- Diagnosis of acute promyelocytic leukemia
- Diagnosis of acute bilineal/biphenotypic leukemia
- History of a different malignancy unless disease free for at least 5 years or diagnosed and treated for cervical cancer in situ, basal or squamous cell carcinoma of the skin
- Uncontrolled intercurrent illness that would limit compliance with study requirements
- Disseminated intravascular coagulation
- HIV positive on combination anti-retroviral therapy
- Known active hepatitis B or C
- History of coronary artery disease
- Current or history of congestive heart failure
- History of ventricular arrhythmia
- Patients with mental deficits or psychiatric conditions that preclude them form giving informed consent and following protocol
- Pregnant
Key Trial Info
Start Date :
January 1 2014
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
January 1 2014
Estimated Enrollment :
Patients enrolled
Trial Details
Trial ID
NCT01843179
Start Date
January 1 2014
End Date
January 1 2014
Last Update
February 17 2017
Active Locations (1)
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1
Massachusetts General Hospital
Boston, Massachusetts, United States, 02115