Status:
UNKNOWN
Local Endometrial Injury in Fresh Embryo Transfer Cycles
Lead Sponsor:
McGill University
Conditions:
Infertility
Eligibility:
FEMALE
36-44 years
Phase:
PHASE3
Brief Summary
The application of in-vitro fertilization (IVF) has provided remarkable opportunities for infertile couple to conceive in the last four decades. Historically IVF was performed for patients with bilate...
Detailed Description
HYPOTHESIS 1. Local endometrial injury improves implantation and pregnancy rates 2. Specifically, local endometrial injury during the follicular phase of an IVF cycle improves the implantation and pr...
Eligibility Criteria
Inclusion
- Infertile patients age ≥36 years old.
- Patients who are planned to undergo a second fresh IVF cycle
- Patients who have previously had a fresh IVF-ET and ≥1 frozen - thawed ET in the past and did not achieve a clinical pregnancy \[two or more failed embryo transfers\].
- Ovarian stimulation with a "microdose flare" protocol
- Patients who are scheduled to undergo a single embryo transfer
- Consent in writing to participate in the study.
Exclusion
- Age of \<36 years old.
- Known or suspected intrauterine factor on ultrasound imaging (submucosal fibroid, endometrial polyp, intrauterine adhesions or intramural fibroids causing uterine distortion).
- Endometriosis (documented by laparoscopy or known endometriomas by ultrasound)
- Previous hysteroscopy (since the start of their 1st IVF cycle)
- Patients who does not speak English or French.
- Patients who will be transferred more than one embryo.
Key Trial Info
Start Date :
August 1 2013
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
August 1 2016
Estimated Enrollment :
360 Patients enrolled
Trial Details
Trial ID
NCT01844453
Start Date
August 1 2013
End Date
August 1 2016
Last Update
May 1 2013
Active Locations (1)
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1
McGill University Health Centre
Montreal, Quebec, Canada, H3A1A1