Status:
TERMINATED
Use of Dexmedetomidine in Acute Stroke and Cerebral Vasospasm Interventions
Lead Sponsor:
University Hospitals Cleveland Medical Center
Collaborating Sponsors:
Hospira, now a wholly owned subsidiary of Pfizer
Conditions:
Stroke
Brain Ischemia
Eligibility:
All Genders
18-85 years
Phase:
PHASE2
Brief Summary
Dexmedetomidine is a unique sedative medication able to provide sedation without causing respiratory depression and maintaining neurological functions. Patients having an acute ischemic stroke and nee...
Detailed Description
Precedex is a unique FDA-approved intravenous medication for conscious sedation in that it allows for "arousable" sedation, which is particularly appealing for use in patients with compromised neurolo...
Eligibility Criteria
Inclusion
- Patients with acute ischemic stroke who require endovascular intervention with whom mNIHSS score can be obtained
- Patients with cerebral vasospasm suspiciousness with or without subarachnoid hemorrhage with whom mNIHSS score can be obtained.
Exclusion
- History of severe hepatic disease or severe renal disease (GFR\<20).
- Hemodynamic instability.
- Pregnancy.
- Known allergy to study drug.
- Evidence or history of cardiac electrophysiology instability including uncontrolled hemodynamically unstable complex atrial/ventricular arrhythmia or conduction block at the time of evaluation with the exception of atrial fibrillation, and heart rate less than 60 or systolic blood pressure less than 90.
- Respiratory compromise requiring intubation.
- Any medical (including history of cardiac conduction block, major hepatic or renal disease) or laboratory abnormality that may increase the risk associated with the trial participation or drug administration or may interfere with interpretation of trial results.
Key Trial Info
Start Date :
April 1 2012
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
December 1 2021
Estimated Enrollment :
7 Patients enrolled
Trial Details
Trial ID
NCT01845441
Start Date
April 1 2012
End Date
December 1 2021
Last Update
December 28 2022
Active Locations (1)
Enter a location and click search to find clinical trials sorted by distance.
1
University Hospitals of Cleveland
Cleveland, Ohio, United States, 44106