Status:
COMPLETED
Chemotherapy Plus Endostatin in Advanced Pancreatic Neuroendocrine Tumor
Lead Sponsor:
Peking Union Medical College Hospital
Conditions:
Advanced Well-differentiated Pancreatic Neuroendocrine Tumor
Eligibility:
All Genders
18+ years
Phase:
PHASE2
Brief Summary
Temozolomide or dacarbazine-based chemotherapy combined with endostatin have efficacy in well-differentiated pancreatic neuroendocrine tumor
Eligibility Criteria
Inclusion
- 18 years of age and older
- ECOG ≤2
- Pathologically confirmed locally advanced or metastatic well-differentiated pancreatic neuroendocrine tumor.
- Prior treatment with one-line chemotherapy is allowed, with the exception of prior treatment with temozolomide or dacarbazine or endostatin within the past 6 months
- Disease progressed during or after last therapy
- Minimum of 4 weeks since any major surgery, completion of radiation, or completion of all prior systemic anticancer therapy
- Disease progressed within the past 12 months。
- Patients must have at least one measurable site of disease according to RECIST1.1 criteria that has not been previously irradiated.
- Adequate bone marrow, liver and renal function
- Life expectancy 3 months or more
- Patient informed consent。
Exclusion
- Concurrent use of Octreotide or other drug that may have efficacy in neuroendocrine tumor.
- 2 or more lines of prior chemotherapy。
- Patients who have any severe and/or uncontrolled medical conditions or other conditions that could affect their participation in the study
- Uncontrolled infectious disease。
- Other malignancies within the past 5 years except for adequately treated carcinoma of the cervix or basal or squamous cell carcinoma of the skin
- Uncontrolled brain or leptomeningeal metastases
- Patients with known hypersensitivity to temozolomide or endostatin。
- Patient could not take tablets。
Key Trial Info
Start Date :
April 1 2013
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
March 31 2017
Estimated Enrollment :
14 Patients enrolled
Trial Details
Trial ID
NCT01845675
Start Date
April 1 2013
End Date
March 31 2017
Last Update
April 13 2017
Active Locations (1)
Enter a location and click search to find clinical trials sorted by distance.
1
Division of Medical Oncology, Peking Union Medical College Hospital
Beijing, China, 100730