Status:
UNKNOWN
Neuropathic Pain in Head and Neck Cancer
Lead Sponsor:
M.D. Anderson Cancer Center
Collaborating Sponsors:
National Institute of Dental and Craniofacial Research (NIDCR)
Conditions:
Head and Neck Cancer
Eligibility:
All Genders
18+ years
Brief Summary
The goal of this research study is to learn more about chronic pain associated with cancer treatment.
Detailed Description
If you agree to take part in this study, you will complete the following tests and procedures at the beginning and at the end of the study (on clinic visits, typically around 3-6 months after completi...
Eligibility Criteria
Inclusion
- Aim 1 Discovery Phase: The samples are from a large NIH-funded Genome-wide association study of squamous cell carcinoma of the head and neck (Shete; PI). A total of 2900 "case" patients and 1200 control patients were recruited for the study. In this study, we will only use cases who were: a) Newly diagnosed, untreated, histopathologically confirmed squamous cell carcinoma of the oral cavity, pharynx, or larynx; b) No previous cancers; c) Age 18 years or older; d) white Caucasian.
- Aim 2: a) Newly diagnosed patients (have not had any prior cancer treatment) with loco-regional squamous cell carcinoma of the head and neck, b) Will receive cancer treatment at MDACC or at Ben Taub, c) Are 18 years or older, d) English or Spanish speaking; e) Able to understand the description of the study and give written informed consent; f) Will state that they will receive follow-up at MD Anderson post-treatment or at Ben Taub. This sample will also be included in the Validation Phase of Aim 1. We note that population stratification, i.e., the presence of a systematic difference in allele frequencies between subpopulations in a population possibly due to different ancestry, is an issue for genetic association studies.
- Aim 3: Patients included in aims 1 and 2.
Exclusion
- 1\) Exclusion for Aim 2: a) Patients with distant metastasis (Stage IVC); b. Patients participating in clinical trials/ investigational drugs for pain control. Aim 1 (discovery phase) and Aim 3 will use existing data.
Key Trial Info
Start Date :
October 15 2012
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
December 31 2022
Estimated Enrollment :
838 Patients enrolled
Trial Details
Trial ID
NCT01846286
Start Date
October 15 2012
End Date
December 31 2022
Last Update
May 25 2022
Active Locations (2)
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1
Lyndon B. Johnson General Hospital (LBJ)
Houston, Texas, United States, 77026
2
University of Texas MD Anderson Cancer Center
Houston, Texas, United States, 77030