Status:
COMPLETED
Effects of Estrogen Deficiency on Energy Expenditure
Lead Sponsor:
University of Colorado, Denver
Collaborating Sponsors:
Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Conditions:
Obesity
Eligibility:
FEMALE
20-40 years
Phase:
NA
Brief Summary
Menopause is associated with weight gain, but the reasons why are not clear. In this study, the investigators will determine if reducing estrogen levels causes a decrease in the ability of the body to...
Detailed Description
The purpose of this pilot study is to investigate the role of the female sex hormone estrogen, on metabolism, thermoregulation and energy expenditure. Weight and fat gain increase after the menopause,...
Eligibility Criteria
Inclusion
- Body mass index \< 30 kg/m2
- Normal menstrual cycles
- Premenopausal
Exclusion
- irregular menstrual cycles defined as 2 or more missed cycles in the previous year
- on hormonal contraceptive or menopausal therapy
- positive pregnancy test
- intention to become pregnant or start hormonal contraceptive therapy during the period of study
- lactation
- severe osteopenia or osteoporosis (i.e., proximal femur or lumbar spine t scores \< -2.0)
- abnormal vaginal bleeding
- thyroid dysfunction
- uncontrolled hypertension
- exercising at least 30 minutes per day at a moderate to vigorous intensity \>1 d/wk) over the past 6 months
Key Trial Info
Start Date :
April 1 2013
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
October 1 2016
Estimated Enrollment :
6 Patients enrolled
Trial Details
Trial ID
NCT01846728
Start Date
April 1 2013
End Date
October 1 2016
Last Update
November 18 2019
Active Locations (1)
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1
University of Colorado Anschutz Medical Campus
Aurora, Colorado, United States, 80045