Status:
COMPLETED
Full Length Versus Proximal Renal Arteries Ablation
Lead Sponsor:
The Second Affiliated Hospital of Chongqing Medical University
Conditions:
Hypertension, Resistant to Conventional Therapy
Eligibility:
All Genders
18-75 years
Phase:
NA
Brief Summary
Catheter-based renal sympathetic modification has been documented to be effective option for blood pressure control in patients with resistant hypertension, but the safety is still concerned around wo...
Detailed Description
After baseline assessment was completed, patients with resistant hypertension were enrolled, and randomly divided into two groups. This study is going to recruit 40 patients (group 1 VS group 2 = 1:1)...
Eligibility Criteria
Inclusion
- office systolic blood pressure of 160 mm Hg or more,
- patients had to be on a stable drug regimen of at least 3 antihypertensive medications with no changes for 1 month before enrollment.
- Despite being treated with at least three antihypertensive drugs(including one diuretic), or confirmed intolerance to medications;
- ≥ 18 years old,;
- did not have any known secondary cause of hypertension;
- had a glomerular filtration rate estimated with the modification of diet in renal disease formula, of 45 ml/min/1.73m2 or more.
Exclusion
- patients with type 1 diabetes,
- implanted pacemakers or implantable cardioverter defibrillators;
- pregnant women;
- haemodynamically significant valvular disease;
- patients with renovascular abnormalities(including mild to severe renal artery stenosis, especially caused by atherosclerosis, previous renal stenting or angioplasty, or known dual renal arteries, or diameter of renal artery identified by angiography less than 4 mm and/or length of renal artery less than 2 cm)
Key Trial Info
Start Date :
March 1 2011
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
June 1 2015
Estimated Enrollment :
47 Patients enrolled
Trial Details
Trial ID
NCT01848275
Start Date
March 1 2011
End Date
June 1 2015
Last Update
July 17 2017
Active Locations (1)
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1
2ndChongqingMU
Chongqing, Chongqing Municipality, China, 400010