Status:
COMPLETED
Effect of GOS Supplementation on Amoxicillin-treated Gut Microbiota From Healthy Adults
Lead Sponsor:
Wageningen University
Conditions:
Colonic Diseases [C06.405.469.158]
Eligibility:
All Genders
18-40 years
Phase:
NA
Brief Summary
Prebiotics are thought to be a potential means to prevent antibiotic-associated diarrhoea because of their ability to stimulate beneficial bacteria. In-vitro results showed a promising recovery of Bif...
Eligibility Criteria
Inclusion
- Age: 18-40 \*
- BMI: 18.5-25 kg/m2
- Stable weight over the last 6 months
- Western diet
- Availability of information about birth by caesarean section and breast-feeding
- Regular defecation (\~1day)
- Healthy as judge by the participant himself
- Having signed the informed consent form
Exclusion
- Smoking or drug use
- Pregnant (include planning to be or gave birth in the last 6 months) or lactating woman
- Using contraceptive pill
- Gastro-intestinal diseases (e.g. irritable bowel syndrome, inflammatory bowel disease)
- Traveling to an Asian, African or south American country \< 6 months before the study
- Hypersensitivity or food allergy for products used in this study (e.g. Lactose, Penicillin)
- Having hepatic disease and renal failure
- Using medication other than paracetamol, acetylsalicylic acid (aspirin), hay fever, asthma
- Not willing to have the family doctor be informed about participation to the study.
- Antibiotic use \< 3 months before the study
- More than 3 antibiotic treatments in the last 2 years.
- Probiotic or prebiotic use \< 1 month before the study\*
Key Trial Info
Start Date :
May 1 2013
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
July 1 2013
Estimated Enrollment :
12 Patients enrolled
Trial Details
Trial ID
NCT01848535
Start Date
May 1 2013
End Date
July 1 2013
Last Update
November 20 2013
Active Locations (1)
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1
Laboratory of Food Chemistry
Wageningen, Netherlands, 6703HD