Status:
COMPLETED
Study of Dexmedetomidine in Spine Surgery
Lead Sponsor:
University of Virginia
Conditions:
Collapse of Thoracic Vertebra
Collapse of Lumbar Vertebrae
Eligibility:
All Genders
18-80 years
Phase:
PHASE4
Brief Summary
The investigators will conduct a prospective randomized double blind study comparing methadone plus methadone and intraoperative dexmedetomidine in multi-level spine surgery in two randomized groups. ...
Detailed Description
Patients presenting for thoracic and/or lumbar spine surgery with neuromonitoring (MEP/SSEP/EMG)will be recruited. Standard anesthesia monitoring will be performed. Randomized to a placebo or dexmedet...
Eligibility Criteria
Inclusion
- Age 18-80 years of age
- Elective multi-level thoracic and/or lumbar spine surgery requiring SSEP, EMG or MEP monitoring
Exclusion
- Emergency spine surgery
- Age \< 18 years
- Pregnant patients
- Advanced heart block: Mobitz type II block or atrio-ventricular dissociation in a previous EKG.
- Any individual with stage 4 or greater chronic kidney disease (eGFR\< 30 ml/min) and/or requiring dialysis or liver failure defined as a history of cirrhosis or fulminant hepatic failure
- Any individuals on preoperative methadone therapy
- Preoperative dexmedetomidine use
- Preoperative systolic hypertension defined by a systolic blood pressure greater than 150 mmHg in the surgical admission suite
- Enrolled in another study within 30 days
Key Trial Info
Start Date :
August 1 2012
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
May 1 2015
Estimated Enrollment :
142 Patients enrolled
Trial Details
Trial ID
NCT01850017
Start Date
August 1 2012
End Date
May 1 2015
Last Update
May 5 2017
Active Locations (1)
Enter a location and click search to find clinical trials sorted by distance.
1
University of Virginia
Charlottesville, Virginia, United States, 22908