Status:
COMPLETED
Efficacy of Low-dose Intra-articular Tranexamic Acid in Total Knee Replacement
Lead Sponsor:
Mahidol University
Conditions:
Primary Osteoarthritis of Knee Nos
Eligibility:
All Genders
50+ years
Phase:
NA
Brief Summary
The purpose of this study is to determine 1) the effective dosage of intra-articular tranexamic acid injection for controlling blood loss and blood transfusion requirement in conventional total knee r...
Eligibility Criteria
Inclusion
- patients diagnosed as primary knee osteoarthritis and underwent unilateral primary cemented conventional total knee replacement
- no risk of abnormal bleeding tendency or bleeding disorder (normal coagulogram, serum creatinine \< 2.0 mg/dL, stop nonsteroidal anti-inflammatory drugs and antiplatelet drugs more than 7 days
- no contra-indication for tranexamic acid use (no active intravascular clotting process, no acquired defective colour vision, no subarachnoid hemorrhage, no hypersensitivity to TXA, and no any of history of serious adverse effects, thrombotic disorder and hematuria)
Exclusion
- incomplete data collection, for example, malfunctioned drain or accidental drain removal.
Key Trial Info
Start Date :
January 1 2010
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
January 1 2012
Estimated Enrollment :
152 Patients enrolled
Trial Details
Trial ID
NCT01850394
Start Date
January 1 2010
End Date
January 1 2012
Last Update
December 13 2013
Active Locations (1)
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1
Ramathibodi Hospital
Bangkok, Thailand, 10400