Status:

COMPLETED

Imipenem Versus Cefepime in Spontaneous Bacterial Peritonitis and to Evaluate the Risk Factors for Treatment Failure

Lead Sponsor:

Institute of Liver and Biliary Sciences, India

Conditions:

Spontaneous Bacterial Peritonitis

Eligibility:

All Genders

18-65 years

Phase:

NA

Brief Summary

1. All consecutive patients with Cirrhosis and ascites admitted to ILBS (Institute of Liver \& Biliary Sciences) will be evaluated for the presence of SBP (Spontaneous Bacterial Peritonitis) by asciti...

Detailed Description

Baseline evaluation: Baseline clinical, laboratory and disease severity parameters will be evaluated for each study patient. 1. Etiology of cirrhosis. 2. Severity of liver disease. CTP (Child-Turcot...

Eligibility Criteria

Inclusion

  • \- Cirrhotic Patients with SBP (Spontaneous Bacterial Peritonitis) having any of the following risk factors would be considered as 'Difficult to Treat SBP' and would be included -
  • Nosocomial SBP: occurence of SBP (Spontaneous Bacterial Peritonitis) after 48 hours of hospital admission, or
  • Prior ascitic fluid infection with 3rd generation cephalosporin resistant organism, or
  • No response to treatment with 3rd generation cephalosporins after 48 hours.

Exclusion

  • Age less than 18 years.
  • Cirrhotics with SBP (Spontaneous Bacterial Peritonitis) managed as outpatients.
  • Post liver transplant, HIV patients.
  • Patients on systemic chemotherapy, immunosuppressant drugs.
  • Growth of bacteria resistant to intervention drugs in ascitic fluid culture.

Key Trial Info

Start Date :

December 1 2012

Trial Type :

INTERVENTIONAL

Allocation :

ACTUAL

End Date :

December 1 2015

Estimated Enrollment :

175 Patients enrolled

Trial Details

Trial ID

NCT01852630

Start Date

December 1 2012

End Date

December 1 2015

Last Update

November 22 2016

Active Locations (1)

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1

Institute of Liver & Biliary Sciences (ILBS)

New Delhi, National Capital Territory of Delhi, India, 110070