Status:
COMPLETED
Hippocampal Metabolism and Function in Patients With Type 1 Diabetes
Lead Sponsor:
University of Minnesota
Conditions:
Hypoglycemia
Diabetes Mellitus
Eligibility:
All Genders
20-70 years
Brief Summary
The hippocampus is an area of brain which plays an essential role in learning and memory processing and is thought to be particularly vulnerable to effects of hypoglycemia (low blood glucose). The goa...
Detailed Description
In this study we will examine hippocampal neurochemical profile and glucose transport kinetics using magnetic resonance spectroscopy (MRS) in patients with type 1 diabetes and hypoglycemia unawareness...
Eligibility Criteria
Inclusion
- diagnosis of type 1 diabetes, hemoglobin A1C \<9%. Alternatively, subject should be a healthy control.
Exclusion
- Exclusion criteria for both groups of subjects include history of stroke, seizures, neurosurgical procedures, or arrhythmias, and use of drugs that can alter glucose metabolism (other than insulin for the patients with diabetes). Subjects must also meet requirements for a study in the magnet, which includes weight less than 300 lbs. and the absence of metallic substances in their body.
Key Trial Info
Start Date :
May 1 2013
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
October 31 2017
Estimated Enrollment :
57 Patients enrolled
Trial Details
Trial ID
NCT01852968
Start Date
May 1 2013
End Date
October 31 2017
Last Update
December 15 2021
Active Locations (1)
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1
Clinical and Translational Science Institute and Center for Magnetic Resonance Research, University of Minnesota
Minneapolis, Minnesota, United States, 55455