Status:
UNKNOWN
Depression in Adolescents. A Cerebral Structural, Diffusion, and Functional Magnetic Resonance Imaging Study
Lead Sponsor:
Centre Hospitalier St Anne
Collaborating Sponsors:
CENIR Centre de Neuroimagerie de Recherche, Paris
Inserm CEA Research unit U1000 (Neuroimaging in psychiatry)
Conditions:
Adolescent Depression
Eligibility:
All Genders
15-18 years
Phase:
NA
Brief Summary
Adolescence is a critical period for the development of depressive disorders. As adolescence also is a critical period for brain maturation, it may be hypothesized that maturation changes in emotional...
Detailed Description
Adolescence is a key development period for neurobiological processes underlying emotional and cognitive functions in adulthood. The pathophysiology of mood disorders has recently been associated with...
Eligibility Criteria
Inclusion
- Depressed adolescents:
- Teenagers of both sexes, from 15 to 18 years old, without contreindications in magnetic fields
- affiliation to a Social insurance
- Informed consent signed by the holders of the parental rights (a specific information note to the teenager)
- Diagnosis DSM-IV-TR ( 2000 ) of depressive Disorder of the humor without psychotic characteristics. The symptoms will have to be persistent for 3 weeks, in spite of a coverage of support ( 2 consultations).
Exclusion
- Ferromagnetical Material in the body
- Claustrophobia, Syndrom of post-traumatic stress, Obsessive-compulsive Disorder, Disturb Tricks, Disturbs abuse of substances
- Intrusive disorder of the development, Disturbs hyperactivity deficit of the attention, Disorders of the conducts, Schizophrenia
- Current antidepressant or antipsychotic psychotropic Treatment for more than 15 days in effective doses
- Current somatic pathology, or pregnancy (urinary test of pregnancy in case of doubt)
- Histories of cranial trauma or neurological pathology, or of lower born weight in 800g
- History of electroconvulsivotherapy in the previous 6 months
- Refusal to give his(her) consent or to be revised on one year after inclusion
- Healthy adolescents: will be screened to be matched to the patients according to age and sex. They will have no psychiatric diagnosis, and no family history of psychiatric conditions.
Key Trial Info
Start Date :
August 31 2013
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
March 1 2018
Estimated Enrollment :
80 Patients enrolled
Trial Details
Trial ID
NCT01857518
Start Date
August 31 2013
End Date
March 1 2018
Last Update
October 20 2017
Active Locations (1)
Enter a location and click search to find clinical trials sorted by distance.
1
Cochin Hospital
Paris, France, 75006