Status:
COMPLETED
Losartan in Decompensated Heart Failure
Lead Sponsor:
InCor Heart Institute
Conditions:
Congestive Heart Failure
Low Cardiac Output
Eligibility:
All Genders
Phase:
PHASE4
Brief Summary
The dual blockade of the renin-angiotensin-aldosterone system with an angiotensin-converting enzyme inhibitor and an angiotensin-receptor blocker used together in heart failure patients has been demon...
Detailed Description
The inclusion criteria were hospitalization for decompensated heart failure defined by worsening of symptoms until fatigue or dyspnea at rest, low cardiac output defined by the clinical-hemodynamic pr...
Eligibility Criteria
Inclusion
- hospitalization for decompensated heart failure
- dobutamine dependence
- ejection fraction \< 0.45
- taking angiotensin-converting enzyme inhibitor
Exclusion
- serum creatinine \> 3.0 mg/dL
- serum potassium \> 6.0 mEq/L
- systolic blood pressure \< 70 mm Hg
- aortic stenosis
- acute coronary syndrome in the previous 2 months
Key Trial Info
Start Date :
September 1 2008
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
March 1 2011
Estimated Enrollment :
21 Patients enrolled
Trial Details
Trial ID
NCT01857999
Start Date
September 1 2008
End Date
March 1 2011
Last Update
May 20 2013
Active Locations (1)
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1
Cotoxó Hospital, Heart Institute (InCor), University of São Paulo
São Paulo, São Paulo, Brazil, 05021-010