Status:
WITHDRAWN
Predicting Treatment Response to Stimulants in Adult ADHD Using Functional Magnetic Resonance Imaging
Lead Sponsor:
Massachusetts General Hospital
Conditions:
ADHD
Eligibility:
All Genders
18-55 years
Phase:
PHASE4
Brief Summary
The primary aim of this study is to assess the predictability of treatment response to stimulants in adults with ADHD using functional magnetic resonance This study will be a six-week, open-label stu...
Detailed Description
Certain brain characteristics have been identified in individuals with persistent and remitted ADHD. We predict that neural functional connectivity; specifically decreases in connectivity between the ...
Eligibility Criteria
Inclusion
- Male or female adults ages 18-55 years
- Right handed
- A diagnosis current of childhood onset ADHD, according to the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition (DSM-IV) based on clinical assessment
- A score of \> 20 on the Adult ADHD Investigator Symptom Report Scale (AISRS) or a CGI-Severity score of \> 4 (moderate severity)
Exclusion
- A history of non-response or intolerance to stimulants at adequate doses as determined by the clinician
- Pregnant or nursing females
- Serious, unstable medical illnesses including hepatic, renal, gastroenterological, respiratory, cardiovascular, endocrinologic (thyroid), neurologic (seizure), immunologic, or hematologic disease
- Glaucoma
- Clinically unstable psychiatric conditions including suicidality, homocidality, bipolar disorder, psychosis, or lifetime history of a clinically serious condition potentially exacerbated by a stimulant, such as mania or psychosis
- Tics or diagnosis of Tourette's syndrome
- Current (within 3 months) DSM-IV criteria for abuse or dependence with any psychoactive substance other than nicotine
- Current use of psychotropic medications
- Current use of MAO Inhibitor or use within the past two weeks
- Claustrophobia or an standard contraindications to MRI scanning (metal in body)
- Investigator and his/her immediate family; defined as the investigator's spouse, parent, child, grandparent or grandchild
Key Trial Info
Start Date :
April 1 2015
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
April 1 2015
Estimated Enrollment :
Patients enrolled
Trial Details
Trial ID
NCT01858064
Start Date
April 1 2015
End Date
April 1 2015
Last Update
April 28 2015
Active Locations (1)
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1
Massachusetts General Hospital
Boston, Massachusetts, United States, 02114