Status:
COMPLETED
Intestinal Bacteria and Ocular Inflammatory Disease
Lead Sponsor:
National Eye Institute (NEI)
Conditions:
Uveitis
Eligibility:
All Genders
18-120 years
Brief Summary
Background: \- Uveitis is a general term describing a group of inflammatory diseases of the eye. The causes of uveitis are not fully understood. Researchers want to look at bacteria in the body that ...
Detailed Description
Objective: What precipitates ocular inflammatory episodes remains unknown, but a possible potentiating factor is the microbiome. The microbiome has become increasingly studied with the advent of new t...
Eligibility Criteria
Inclusion
- INCLUSION CRITERIA:
- Inclusion Criteria for Uveitis Participants
- Participant must be 18 years of age or older.
- Participant must have a diagnosis of:
- Uveitis (or ocular inflammatory disorder)
- Participant must be able to undergo slit lamp biomicroscopy.
- Participant must understand and sign the protocol s informed consent document.
- Inclusion Criteria for Healthy Volunteers
- Participant must be 18 years of age or older.
- Participant must be able to undergo slit lamp biomicroscopy.
- Healthy controls will be age-and sex-matched individuals with no personal history of uveitis or other rheumatologic/autoimmune diseases (such as arthritis, inflammatory bowel disease, type 1 diabetes mellitus, psoriasis, Sjorgren s syndrome or multiple sclerosis) and no current use of corticosteroids, disease modifying antirheumatic drugs (DMARDs) including those with antibiotic properties (e.g., gold salts, sulfasalazine, hydroxychloroquine, minocycline) or any immunomodulatory drugs.
- Participant must understand and sign the protocol s informed consent document.
- EXCLUSION CRITERIA:
- Exclusion Criteria for Uveitis Participants
- Participants who are unable to provide informed consent.
- Recent (\<3 months prior) use of any antibiotic therapy
- Current consumption of probiotics
- Current extreme diet (parenteral nutrition, macrobiotic diet, etc.)
- Known gastrointestinal (GI) tract neoplasm
- Recent GI tract infection (gastroenteritis, colitis, diverticulitis, appendicitis) within the last month
- Chronic unexplained diarrhea
- Participant has or had a significant active infection (an infection requiring treatment as determined by the investigator) that required systemic antibiotic treatment within the past three months
- Participant has any GI tract surgery leaving permanent residua (e.g., gastrectomy; bariatric surgery; colectomy)
- Participant has inflammatory bowel disease (IBD)
- Participant is pregnant or lactating.
- Exclusion Criteria for Healthy Volunteers
- Recent (\<3 months prior) use of any antibiotic therapy
- Current consumption of probiotics
- Current extreme diet (parenteral nutrition, macrobiotic diet, etc.)
- Known gastrointestinal (GI) tract neoplasm
- Recent GI tract infection (gastroenteritis, colitis, diverticulitis, appendicitis) within the last month
- Chronic unexplained diarrhea
- Participant has or had a significant active infection (an infection requiring treatment as determined by the investigator) that required systemic antibiotic treatment within the past three months
- Participant has any GI tract surgery leaving permanent residua (e.g., gastrectomy; bariatric surgery; colectomy)
- Participant has inflammatory bowel disease (IBD)
- Participant is pregnant or lactating.
Exclusion
Key Trial Info
Start Date :
August 27 2013
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
Estimated Enrollment :
131 Patients enrolled
Trial Details
Trial ID
NCT01859299
Start Date
August 27 2013
Last Update
December 19 2025
Active Locations (1)
Enter a location and click search to find clinical trials sorted by distance.
1
National Institutes of Health Clinical Center
Bethesda, Maryland, United States, 20892