Status:
COMPLETED
Plasma Triglyceride Extraction by The Muscle
Lead Sponsor:
Mayo Clinic
Collaborating Sponsors:
American Diabetes Association
Conditions:
Obesity
Insulin Resistance
Eligibility:
All Genders
18-50 years
Phase:
PHASE1
Brief Summary
Increased accumulation of fat into the muscles is associated with what is called insulin-resistant state, which is a pre-diabetic state. The purpose of this research is to find out how fat circulating...
Eligibility Criteria
Inclusion
- Body mass index (BMI): \< 25 kg/m2 or \> 30 kg/m2;
- Insulin sensitivity index (ISI): insulin-sensitive ISI ≥ 7, insulin-resistant ISI ≤ 5.
Exclusion
- Medication or supplements known to affect either endothelial function or lipid metabolism (i.e. arginine, protein, fish oil)
- Acute illness
- Uncontrolled metabolic disease, including liver or renal disease
- Atrial fibrillation, history of syncope, limiting or unstable angina, congestive heart failure, known or suspected right-to-left, bi-directional or transient right-to-left cardiac shunts
- Cardiac pacemaker or other medical device implanted in the body
- Pulmonary hypertension or other unstable cardiopulmonary conditions
- ECG documented abnormalities or valvular disease
- Low hemoglobin or hematocrit (i.e., lower than accepted laboratory values)
- History of hypertension or elevated blood pressure (systolic, \>140 mmHg or a diastolic, \>95 mmHg)
- History of hyperlipidemia or plasma triglyceride concentration \>200 mg/dl
- Diagnosed diabetes, or 2-h plasma glucose \>200 mg/dl during an oral glucose tolerance test
- Current participation in a weight-loss regimen, including extreme dietary practices
- Use of anabolic steroids or corticosteroids (within 3 months)
Key Trial Info
Start Date :
April 1 2013
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
August 31 2016
Estimated Enrollment :
33 Patients enrolled
Trial Details
Trial ID
NCT01860911
Start Date
April 1 2013
End Date
August 31 2016
Last Update
October 8 2021
Active Locations (1)
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1
Mayo Clinic in Arizona
Scottsdale, Arizona, United States, 85259