Status:
COMPLETED
Investigation Into the Role of GTN & RIPC in Cardiac Surgery
Lead Sponsor:
University College, London
Collaborating Sponsors:
University College London Hospitals
Conditions:
Myocardial Reperfusion Injury
Eligibility:
All Genders
18+ years
Phase:
PHASE3
Brief Summary
The purpose of this study is to determine whether Glyceryl Trinitrate (GTN) reduces injury to the heart during heart-lung bypass surgery in combination with the newer technique of remote ischaemic pre...
Detailed Description
Ischaemic heart disease is a leading cause of mortality in the western world. A number of patients undergo coronary artery bypass graft (CABG) surgery as treatment for ischaemic heart disease. With th...
Eligibility Criteria
Inclusion
- Age \> 18 years all patients admitted for on- pump CABG and/or valve surgery
- Able to give consent
Exclusion
- Allergies to excipients of IMP and placebo
- Chronic Renal failure (eGFR\<30 ml/min/kg)
- Severe liver disease
- Peripheral arterial disease
- Pregnant or lactating women
Key Trial Info
Start Date :
January 1 2014
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
February 1 2019
Estimated Enrollment :
192 Patients enrolled
Trial Details
Trial ID
NCT01864252
Start Date
January 1 2014
End Date
February 1 2019
Last Update
September 25 2019
Active Locations (1)
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1
The Heart Hospital, UCL Hospitals NHS Trust
London, United Kingdom, NW1 2PG