Status:
COMPLETED
Fat Distribution and Glucose Metabolism in Williams Syndrome
Lead Sponsor:
Massachusetts General Hospital
Conditions:
Williams Syndrome
Eligibility:
All Genders
14-70 years
Brief Summary
Williams Syndrome (WS) is a genetic syndrome with features that may include vascular stenoses, neuro-developmental changes, and a variety of endocrine and metabolic abnormalities, including impaired g...
Eligibility Criteria
Inclusion
- Inclusion Criteria
- M or F age 14-70yo
- Diagnosis of WS confirmed by FISH or chromosomal microarray (WS only)
- Availability of a parent or guardian to participate in the consent process (all WS, and controls \<18yo)
- Exclusion Criteria
- History of weight loss surgery or liposuction
- Use of weight-lowering drugs
- Positive urine pregnancy test (females only)
- Obesity or abnormal fat distribution due to a known secondary cause (except WS) such as Cushing syndrome, HIV-infection, etc.
- Known diabetes will preclude administration of the OGTT but not participation in other aspects of the study.
Exclusion
Key Trial Info
Start Date :
December 1 2013
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
February 1 2016
Estimated Enrollment :
24 Patients enrolled
Trial Details
Trial ID
NCT01864304
Start Date
December 1 2013
End Date
February 1 2016
Last Update
January 10 2017
Active Locations (1)
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1
Massachusetts General Hospital
Boston, Massachusetts, United States, 02114