Status:
COMPLETED
Target Temperature Management In Myocardial Infarction - A Pilot Study
Lead Sponsor:
Medical University of Vienna
Conditions:
ST-elevation Myocardial Infarction
Eligibility:
All Genders
18-75 years
Phase:
NA
Brief Summary
The primary goal in the treatment of acute myocardial infarction is to reperfuse the ischemic myocardium to reduce infarct size. Animal data and human data suggest that whole-body cooling to temperatu...
Eligibility Criteria
Inclusion
- Age between 18 and 75 years
- Immediately transfer to cath-lab is possible
- Anterior or inferior ST-Elevation myocardial infarction
- ST-Segment elevation of \>0.2mV in 2 or more anatomically contiguous leads
- Duration of symptoms \<6 hours
Exclusion
- Participation in another study
- Patients presenting with cardiac arrest
- Tympanic temperature of \<35.0°C prior enrolment
- Thrombolysis therapy
- Previous myocardial infarction in medical history
- Previous percutaneous coronary intervention or coronary artery bypass graft
- Severe heart failure (defined as a New York Heart Association (NYHA) score of III or IV), Killip class II through IV at presentation
- Clinical signs of infection
- End-stage kidney disease or hepatic failure
- Recent stroke (within the last six month)
- Conditions that may be exacerbated by hypothermia, such as haematological dyscrasias, oral anticoagulant treatment with international normalized radio \>1.5, severe pulmonary disease
- Pregnancy. Women of childbearing potential are excluded
- Allergy to meperidine, buspirone, magnesium, or polyvinyl chloride
- Use of a monoamine oxidase inhibitor such as selegiline in the previous 14 days
Key Trial Info
Start Date :
September 1 2011
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
May 1 2013
Estimated Enrollment :
19 Patients enrolled
Trial Details
Trial ID
NCT01864343
Start Date
September 1 2011
End Date
May 1 2013
Last Update
May 29 2013
Active Locations (1)
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1
Medical University of Vienna
Vienna, Vienna, Austria, 1090