Status:
COMPLETED
Phase II Trial of Carboplatin, 5-FU and Cetuximab in Elderly Fit (no Frailty) Patients With Recurrent/Metastatic HNSCC
Lead Sponsor:
Groupe Oncologie Radiotherapie Tete et Cou
Collaborating Sponsors:
Gustave Roussy, Cancer Campus, Grand Paris
Conditions:
Metastatic or Recurrent Head and Neck Squamous Cell Cancer
Eligibility:
All Genders
70+ years
Phase:
PHASE2
Brief Summary
The aim of the trial is to evaluate the clinical benefit (efficacy, safety, preservation of autonomy) of cetuximab-carboplatin-5FU combination as first line treatment of recurrent or metastatic head a...
Eligibility Criteria
Inclusion
- Age greater than or equal to 70 years
- patient enrolled in ELAN-ONVOCAL study and evaluated as fit (harmonious aging) by GERICO screening method for geriatric frailty
- life expectancy superior to 12 weeks
- creatinin clearance \> ou equal to 50ml/mn calculated using Modification of Diet in Renal Disease (MDRD) formula
- hematologic function : absolute neutrophil count \> 1.5 x 10\^9/l, platelets \> 100 x 10\^9/l, hemoglobin \> 9,5 g/dl
- liver function : total bilirubin inferior to 1,25 x Upper limit of normal (ULN), SGOT/SGPT inferior to 5 x ULN, PAL inferior to 5 x ULN
- PS \< 2
- The disease:
- histologically proven head and neck squamous cell carcinomas
- recurrent or metastatic. Visceral metastases or locoregional recurrence unsuitable for curative locoregional treatment: unsuitable for primitive tumor surgery due to local extension (evidently authorized for lymph nodes) and unsuitable for radiotherapy for primitive tumor (or already performed) due to metastatic dissemination and the absence of indication for re-irradiation of primitive tumor.
- Presence of at least one measurable lesion (defined by RECIST criteria) by CT scan or IRM
- asymptomatic cerebral metastases authorized
- General:
- signed Informed Consent Form
- affiliated to the French social security system (or a beneficiary of this system) according to the provisions of the law of 9 August 2004
Exclusion
- Previous systemic chemotherapy, except for chemotherapy as part of multimodal treatment for locally advanced cancer completed more than 6 months prior to study enrollment
- Known contraindication specific to one of study treatments (particularly cardiac for 5FU)
- Known dihydropyrimidine dehydrogenase deficiency (DPD deficiency).
- Patients considered as "unfit " (fragile) by GERICO screening method for geriatric frailty
- Irradiation within 4 weeks prior to study enrollment.
- Nasopharyngeal, rhinopharyngeal or maxillary sinus carcinoma.
- Presence of infection (infection requiring intravenous antibiotics), including tuberculosis and HIV infection (human immunodeficiency virus).
- Concomitant treatment with other antitumor immunotherapy or hormonal therapy.
- Other antitumor concomitant therapies.
- Prior treatment with EGFR-targeted therapy (epidermal growth factor receptor).
- Treatment with one of study drugs within 30 days prior to study enrollment.
- Presence of documented symptomatic brain or leptomeningeal metastases
- Clinically significant coronaropathy or antecedent myocardial infarction within 12 months prior to study enrollment or high-risk uncontrolled arrhythmias or uncontrolled heart failure.
- Medically uncontrolled arterial hypertension
- Other prior or concomitant cancer, with exception for carcinoma in situ of the uterine cervix, or for cutaneous basal cell carcinoma within 5 years prior to study enrollment.
- Presence of medical or physiological factors susceptible to modify patient compliance with study protocol and follow-up or Informed Consent Form signing.
- Known allergy or hypersensibility to monoclonal antibodies (bevacizumab, cetuximab), or to other chemotherapies of the study or to their excipients
Key Trial Info
Start Date :
September 1 2013
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
May 26 2020
Estimated Enrollment :
85 Patients enrolled
Trial Details
Trial ID
NCT01864772
Start Date
September 1 2013
End Date
May 26 2020
Last Update
August 19 2022
Active Locations (2)
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1
Hôpital de la Dracénie
Draguignan, France, 83300
2
Institut Gustave Roussy
Villejuif, France, 94805