Status:
TERMINATED
A Study Into the Effect of Seprafilm in Open Total Thyroidectomy
Lead Sponsor:
National Cancer Centre, Singapore
Collaborating Sponsors:
Singapore General Hospital
Conditions:
Thyroid Carcinoma
Eligibility:
All Genders
21-75 years
Phase:
NA
Brief Summary
The investigators intend to determine the role of Seprafilm, a popular anti-adhesive agent in minimising internal adhesion formation in the neck after thyroid surgery and therefore reduce swallowing d...
Detailed Description
Thyroid surgery not only constitutes one of the main pillars in the treatment of thyroid cancers, but is also employed in the management of symptomatic goitres. Occasionally, it is mandated in patient...
Eligibility Criteria
Inclusion
- Age 21-75
- Histological confirmation of differentiated thyroid cancer requiring surgery, symptomatic goiters, thyroid nodules requiring histological analysis, or thyrotoxicosis poorly controlled by medication.
- Undergoing total thyroidectomy
Exclusion
- Previous neck surgery
- Previous neck radiotherapy
- Patients with a known history of keloids
- Patients with a known history of motility disorders in the upper gastrointestinal tract and preexisting swallowing difficulty.
- Patients with metastatic disease; patients with disease that would require postop radiation therapy, radionuclide iodine therapy and any adjuvant therapies.
- Patients with advanced disease that would require radical or modified neck dissection
- Patients with lobe larger than 10 cm, or nodule larger than 8 cm which require extensive dissection that may confound the study
- Patients with connective tissue diseases and chronic diseases on long-term medications that may interfere with wound healings such as steroids
Key Trial Info
Start Date :
May 1 2013
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
September 1 2014
Estimated Enrollment :
19 Patients enrolled
Trial Details
Trial ID
NCT01865838
Start Date
May 1 2013
End Date
September 1 2014
Last Update
April 12 2017
Active Locations (2)
Enter a location and click search to find clinical trials sorted by distance.
1
Singapore General Hospital
Singapore, Singapore, 169608
2
National Cancer Centre Singapore
Singapore, Singapore, 169610