Status:
COMPLETED
Severe Impairment of Solute-Free Water Clearance in Patients With HIV Infection
Lead Sponsor:
Hospital Italiano de Buenos Aires
Conditions:
HIV Infection
Eligibility:
All Genders
18+ years
Brief Summary
The objective of the present study is to analyze the overall tubular function, and in particular that from the proximal tubule and the thick ascending loop of Henle (TALH) in patients with HIV infecti...
Detailed Description
Renal disease is a well recognized complication among patients with HIV infection. Either viral infection itself and the use of some antiretroviral drugs contribute to this serious non AIDS-defining c...
Eligibility Criteria
Inclusion
- Inclusion criteria are as follows: adult patients (≥18 years old) with confirmed chronic HIV-1 infection who agreed to provide written informed consent. Patients under antiretroviral treatment must had a stable regimen for over six months and undetectable (\<50 copies/ml) viral load for at least three months. At study entry all selected patients were confirmed as having normal physical examination, routine clinical laboratory including urinalysis, as well as renal and cardiac ultrasound.
Exclusion
- Exclusion criteria include patients with acute HIV infection (\< 6 months of disease), personal history of nephropathy, plasma creatinine ≥1.3 mg/dl, Glomerular filtration rate ≤60ml/min/1.73 m² (as determined by Modification of Diet in renal Disease formula), presence of glucosuria/proteinuria (measured in spot urine sample), prior heart failure, concurrent opportunistic infection, chronic active hepatitis B or C, and use of potentially nephrotoxic agents in the prior week before the test (e.g diuretics, angiotensin converting enzyme antagonists, Angiotensin II receptor antagonists or non-steroidal anti-inflammatory agents).
Key Trial Info
Start Date :
January 1 2010
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
April 1 2012
Estimated Enrollment :
30 Patients enrolled
Trial Details
Trial ID
NCT01869010
Start Date
January 1 2010
End Date
April 1 2012
Last Update
September 9 2025
Active Locations (1)
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1
Hospital Italiano de Buenos Aires - Infectious Diseases Section
Buenos Aires, Buenos Aires F.D., Argentina, 1181