Status:
UNKNOWN
Respiratory Muscle Function in COPD Exacerbations
Lead Sponsor:
Parc de Salut Mar
Conditions:
Chronic Obstructive Pulmonary Disease (COPD)
Eligibility:
All Genders
40-80 years
Phase:
NA
Brief Summary
There is evidence that noninvasive mechanical ventilation (NIV) is effective in the treatment of severe exacerbations of COPD presenting respiratory acidosis. The aim of the study is to evaluate the ...
Eligibility Criteria
Inclusion
- Diagnosis of COPD according to international guidelines ( GOLD)
- COPD exacerbation requiring hospitalization
- Initial blood gases: PaCO2\> 50 mm Hg and pH\> 7.35.
- If the patient does not have COPD diagnosis at the time of inclusion, it could be included if the diagnosis is confirmed within three months after the exacerbation.
Exclusion
- Patients with a pH below 7.35
- Patients with intubation criteria
- Other chronic respiratory diseases (fibrothorax, cystic fibrosis, significant ribcage alterations)
- Neuromuscular Diseases
- Significant associated chronic systemic diseases (severe liver disease, chronic renal failure requiring dialysis, severe heart disease and active neoplasia)
- COPD exacerbation secondary to pulmonary embolism, pneumonia or pneumothorax
- Patients in active treatment with CPAP or home ventilation
Key Trial Info
Start Date :
June 1 2013
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
December 1 2015
Estimated Enrollment :
46 Patients enrolled
Trial Details
Trial ID
NCT01869387
Start Date
June 1 2013
End Date
December 1 2015
Last Update
June 5 2013
Active Locations (1)
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1
Hospital del Mar (Servei de Pneumología)
Barcelona, Barcelona, Spain, 08003