Status:
COMPLETED
Nocturnal Breathing and Sleep in Patients With Chronic Obstructive Pulmonary Disease Staying at Altitude
Lead Sponsor:
University of Zurich
Conditions:
Chronic Obstructive Pulmonary Disease
Eligibility:
All Genders
18-75 years
Phase:
NA
Brief Summary
The purpose of this study is to evaluate whether nocturnal breathing and sleep of patients with chronic obstructive pulmonary disease (COPD) are disturbed during a stay at moderate altitude.
Detailed Description
This randomized cross-over trial evaluates the hypothesis that patients with chronic obstructive pulmonary disease experience nocturnal hypoxemia, periodic breathing and sleep disturbances when stayin...
Eligibility Criteria
Inclusion
- chronic obstructive pulmonary disease (COPD), GOLD grade 2-3
- residents at low altitude (\<800 m)
Exclusion
- Unstable condition, COPD exacerbation
- Mild (GOLD 1) or very severe COPD (GOLD 4)
- requirement for oxygen therapy at low altitude residence
- hypoventilation
- pulmonary hypertension
- more than mild or unstable cardiovascular disease
- use of drugs that affect respiratory center drive
- internal, neurologic or psychiatric disease that interfere with protocol compliance including current heavy smoking (\>20 cigarettes per day), inability to perform 6 min walk test.
- previous intolerance to moderate altitude (\<2600m).
- Exposure to altitudes \>1500m for \>2 days within the last 4 weeks before the study.
- Pregnant or nursing patients
Key Trial Info
Start Date :
June 1 2013
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
December 1 2013
Estimated Enrollment :
50 Patients enrolled
Trial Details
Trial ID
NCT01870830
Start Date
June 1 2013
End Date
December 1 2013
Last Update
May 19 2015
Active Locations (1)
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1
University Hospital Zurich, Pulmonary Division
Zurich, Switzerland, CH-8091