Status:
COMPLETED
Residual Curarization and Its Incidence at Tracheal Extubation in China
Lead Sponsor:
Xinmin Wu
Collaborating Sponsors:
Merck Sharp & Dohme LLC
Conditions:
Residual Curarization
Eligibility:
All Genders
18+ years
Brief Summary
This study will assess the residual neuromuscular blockade (NMB) Train-Of-Four (TOF) ratios at tracheal extubation when anesthesiologists have determined that full recovery of neuromuscular function h...
Detailed Description
This is a prospective, multi-site, anesthesiologist and PACU nurse TOF-Watch SX® blinded observational study of surgical patients undergoing elective laparoscopic or open abdominal procedures requirin...
Eligibility Criteria
Inclusion
- Age≥18;
- American Society of Anesthesiologists(ASA) class 1-3;
- Scheduled for elective open or laparoscopic abdominal surgery that is anticipated to last less than 4 hours;
- Administration of general anesthesia and ≥ 1 dose of non-depolarizing neuromuscular blockers for endotracheal intubation or maintenance of neuromuscular blockade;
- Planned for extubation to occur in the OR;
- Signed informed consent.
Exclusion
- Redo surgery on the same hospital admission;
- Pre-established need or expected to require post-operative mechanical ventilation;
- Conditions, surgical procedures, or participant positioning that may interfere with TOF-Watch SX® operation, calibration, or accuracy;
- Anesthesiologist use of objective neuromuscular monitoring during surgery (e.g. mechanomyography, electromyography or related method);
- Pregnancy;
- Participation in any other clinical trial;
- Member or a family member of the personnel of the investigational or Sponsor staff directly involved with this trial.
Key Trial Info
Start Date :
December 1 2012
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
September 1 2015
Estimated Enrollment :
1571 Patients enrolled
Trial Details
Trial ID
NCT01871064
Start Date
December 1 2012
End Date
September 1 2015
Last Update
November 10 2015
Active Locations (32)
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1
Nanfang Hospital of Southern Medical University
Guangzhou, Guangdong, China
2
The First Affiliated Hospital, Sun Yat-sen University
Guangzhou, Guangdong, China
3
ZhuJiang Hospital of Southern Medical University
Guangzhou, Guangdong, China
4
The First Affiliated Hospital of Zhengzhou University
Zhengzhou, Henan, China