Status:
UNKNOWN
Amyloid Accumulation After Mild Traumatic Brain Injury
Lead Sponsor:
Chang Gung Memorial Hospital
Conditions:
Traumatic Brain Injury
Eligibility:
All Genders
30+ years
Phase:
PHASE2
Brief Summary
There will be 200 participants, who aged 30 years or older with TBI in 1,5,10,15 years ago and GCS=13-15 will be recruited. Another group of 200 participants with the same age and gender and without T...
Detailed Description
We will examine the mTBI patients in a long-term follow-up manner by cognitive tests and A-PET. This is a novel study for linking mTBI and AD by solid, reliable methods, in terms of A-PET and cognitiv...
Eligibility Criteria
Inclusion
- Inclusion criteria:
- The individuals are listed in the Taipei medical university traumatic brain injury databank and had TBI in 1, 5, 10 and 15 years ago. There are about 200 individuals undergo telephone interview/invitation, blood test for genotyping and neuropsychological tests. 30 participants will be selected randomly among the 200 individuals.
- mild injury in TBI (initial GCS = 13-15)
- had MRI or CT evaluation after TBI
- aged 30 years or older better
- agreed by principal investigator
- have agreement and have signed the informed consent form by him/herself or his/her legal representative
- Main exclusion criteria:
- participating in another clinical trials which might interfere the current finding.
- not sure the timing of TBI
- contaminant the symptoms with injury, skull fracture, intracranial hemorrhage, craniotomy, and death
- moderate (initial GCS = 9-12) or severe (initial GCS \< 8) injury in TBI
- had wound with gunshot or puncture
- loss of consciousness over 30 minutes after TBI
- loss of memory for over 1 day after TBI
- have no MRI or CT evaluation of brain after TBI or have obstructive ischemia after MRI or CT evaluation
- have uremia, liver cirrhosis, heart failure, pulmonary edema, coagulation disorders and other major diseases
- pregnant woman or emotional instability
- the age less than 18 years (30 years better)
- unable to collect blood sample by peripheral vein
- determination of inappropriate participants in the clinical trail of PI
Exclusion
Key Trial Info
Start Date :
November 1 2012
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
October 1 2013
Estimated Enrollment :
40 Patients enrolled
Trial Details
Trial ID
NCT01871610
Start Date
November 1 2012
End Date
October 1 2013
Last Update
June 7 2013
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