Status:
COMPLETED
Acute Ventilatory Response to Hypoxia During Sedation With Dexmedetomidine Compared to Propofol in Healthy Male Volunteers
Lead Sponsor:
Karolinska University Hospital
Conditions:
Hypoxia
Anesthetics
Eligibility:
MALE
18-40 years
Phase:
PHASE4
Brief Summary
The overall aim with this project is to investigate the effect of dexmedetomidine on control of breathing in healthy volunteers and to compare it with propofol at the same degree of sedation.
Detailed Description
15 volunteers will be investigated for their hypoxic and hypercapnic ventilatory response during sedation with dexmedetomidine and propofol in a randomized cross-over study. 6 volunteers will be inve...
Eligibility Criteria
Inclusion
- Male
- Age 18-40
- American Society of Anesthesiologist´s classification (ASA) 1, i.e. healthy
- No medication
- No allergies
- Non-smoker/no snuff, i.e. no nicotine intake
- Normal weight, BMI \<26
Exclusion
- Snoring
Key Trial Info
Start Date :
May 1 2013
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
September 1 2014
Estimated Enrollment :
11 Patients enrolled
Trial Details
Trial ID
NCT01873612
Start Date
May 1 2013
End Date
September 1 2014
Last Update
February 26 2016
Active Locations (1)
Enter a location and click search to find clinical trials sorted by distance.
1
Department of Anesthesiology, Surgical Sciences and Intensive Care Medicine, Karolinska University Hospital
Stockholm, Sweden, SE-17176