Status:
COMPLETED
From Movement Preparation to Gait Execution in ALS
Lead Sponsor:
Institut National de la Santé Et de la Recherche Médicale, France
Collaborating Sponsors:
Université Paris Ouest-EA 2931-CEntre de Recherches sur le Sport et le Mouvement
Conditions:
Amyotrophic Lateral Sclerosis
Eligibility:
All Genders
18-75 years
Brief Summary
This research program will focus on gait initiation and postural control in Amyotrophic Lateral Sclerosis (ALS) patients, by comparing patients with vs without postural instability (but also in compar...
Detailed Description
Compared to other movement disorders, such as Parkinson Disease (PD), the mechanisms of movement impairment in Amyotrophic Lateral Sclerosis (ALS) have not been a focus of great interest. It is at lea...
Eligibility Criteria
Inclusion
- Between 18 (exclusive) and 75 (inclusive) years old
- With a defined, probable or laboratory possible ALS according to El Escorial18
- With a disease duration between 3 months (inclusive) and 5 years (exclusive)
- Able to walk at least 10 meters without an aid and to perform the foot-tapping task
- Right handed
- Able to understand thoroughly the given information; able to sign the informed consent form (signature of spouse or family relative or acceptable third party is acceptable if the patient is physically unable to sign)
- With a social insurance
Exclusion
- Patients with a fronto temporal dementia (according to Neary' criteria)
- Patients with any concomitant life-threatening disease or any disease or impairment likely to interfere with functional assessment
- Patients with any major evolving psychiatric disorder or major anxiety disorder according to DSM-IV criteria (APA, 1996)
- Patients with contraindications for the MRI scan
Key Trial Info
Start Date :
June 21 2013
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
December 21 2015
Estimated Enrollment :
59 Patients enrolled
Trial Details
Trial ID
NCT01874808
Start Date
June 21 2013
End Date
December 21 2015
Last Update
November 18 2025
Active Locations (1)
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1
Hôpital Pitié-Salpétrière, Département des Maladies du Système Nerveux 47-83 Boulevard de l'Hôpital
Paris, France, 75013