Status:
COMPLETED
Increased Salt Sensitivity of Ambulatory Blood Pressure in Women With a History of Severe Preeclampsia
Lead Sponsor:
University Hospital, Geneva
Conditions:
Preeclampsia
Eligibility:
FEMALE
18-50 years
Phase:
NA
Brief Summary
Cardiovascular diseases are the principal cause of death in women in developed and developing countries and are importantly promoted by hypertension. Salt sensitivity of the blood pressure is consider...
Eligibility Criteria
Inclusion
- women with history of severe preeclampsia (systolic blood pressure ≥160mmHg and/or diastolic blood pressure ≥110 mmHg with severe proteinuria (≥ 5g /24h or 3+ dipstick) and one or more signs of multisystem disease developing after 20 weeks of gestation in previously normotensive women.
- or
- women who had a premature delivery (\<34 weeks) in the context of preeclampsia (systolic blood pressure ≥140mmHg and/or diastolic blood pressure ≥90 mmHg with severe proteinuria (≥ 300 mg /24h or 1+ dipstick)
- age ≤ 50 years
- controls : women and who delivered at term (\> 37 weeks) without pre-eclampsia
Exclusion
- History of :
- hypertension
- diabetes mellitus
- renal or cardiac impairment
- polycystic ovary syndrome
- recent or actual use of anti-inflammatory drugs, diuretics, aspirin, oral contraceptives and hormonal replacement therapy
Key Trial Info
Start Date :
December 1 2009
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
December 1 2012
Estimated Enrollment :
40 Patients enrolled
Trial Details
Trial ID
NCT01874990
Start Date
December 1 2009
End Date
December 1 2012
Last Update
June 11 2013
Active Locations (1)
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1
University Hospitals
Geneva, Switzerland, 1211