Status:
TERMINATED
Hormones Inflammation and Thrombosis
Lead Sponsor:
Johns Hopkins University
Conditions:
Acute Coronary Syndrome
Thrombosis
Eligibility:
FEMALE
18-80 years
Phase:
PHASE4
Brief Summary
The investigators are attempting to determine if the response to aspirin in women is related to the level of estrogen and progesterone that a woman has.
Detailed Description
Thrombosis plays a significant role in both acute coronary syndromes (ACS) and early saphenous vein graft (SVG) failure. Women with coronary heart disease have higher levels of the inflammatory mediat...
Eligibility Criteria
Inclusion
- Women age 18-80
- Signed informed consent.
Exclusion
- History of CAD, Cerebrovascular Accident (CVA) or Peripheral Artery Disease (PAD),
- On chronic aspirin therapy,
- On chronic NSAID therapy.
- Chronic anticoagulation with coumadin,
- Known thrombocytopenia (Platelet count \< 100,000),
- Pregnancy (self-report),
- Currently on any type of contraceptive or hormone replacement therapy,
- Hysterectomy and/or oophorectomy.
- Recent GI bleeding
- Bleeding diathesis
- Chronic Systemic Infection
Key Trial Info
Start Date :
December 1 2012
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
November 1 2013
Estimated Enrollment :
100 Patients enrolled
Trial Details
Trial ID
NCT01875185
Start Date
December 1 2012
End Date
November 1 2013
Last Update
May 7 2018
Active Locations (1)
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1
Johns Hopkins Hospital
Baltimore, Maryland, United States, 21287