Status:
COMPLETED
Non-invasive Brain Stimulation and Cognitive Processing in Depression
Lead Sponsor:
University College, London
Conditions:
Unipolar Major Depressive Disorder
Eligibility:
All Genders
18-60 years
Phase:
NA
Brief Summary
Depression is a serious mental health problem that affects millions. Depression is usually treated using drugs and/or psychotherapy, but neither approach is successful for everyone, and some people do...
Detailed Description
We propose to investigate the effect of applying transcranial direct current stimulation (tDCS) over the left dorsolateral prefrontal cortex (LDLPFC) immediately prior to each of 8 sessions of cogniti...
Eligibility Criteria
Inclusion
- Patients suffering from unipolar major depressive disorder
- First depressive episode onset before 40 years old
- Right-handedness
- English as first language
- Intention to commence a course of cognitive behavioural therapy
Exclusion
- Antidepressant or other psychotropic medication at any time during the study or within previous 4 weeks (8 for fluoxetine)
- Recent illicit drug use
- Prior mixed, manic, or psychotic symptoms or other psychiatric or neurological illness
- Standard exclusion criteria for MRI scanning: pregnancy, breast feeding, any immovable metal in the body, weight above 250 lbs, claustrophobia
- tDCS safety criteria: skin disease or skin treatment that could potentially cause irritation with electrical stimulation
Key Trial Info
Start Date :
July 22 2014
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
September 20 2017
Estimated Enrollment :
30 Patients enrolled
Trial Details
Trial ID
NCT01875419
Start Date
July 22 2014
End Date
September 20 2017
Last Update
May 9 2018
Active Locations (1)
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1
UCL Institute of Cognitive Neuroscience
London, United Kingdom, WC1N 3AR