Status:
UNKNOWN
Alpha-synuclein in Cerebrospinal Fluid to Differentiate Alzheimer's Disease From Lewy Body Disease.
Lead Sponsor:
University Hospital, Strasbourg, France
Conditions:
"Alzheimer's Disease" and "Lewy Body Disease"
Eligibility:
All Genders
45+ years
Phase:
NA
Brief Summary
Patients with memory disorders are experiencing different trends which are difficult to predict. Moreover, the distinction between Lewy body disease and Alzheimer's disease is not easy as both disease...
Eligibility Criteria
Inclusion
- At least 45 years of age
- Subject agrees to participate in the study
- Subject meets the criteria Dubois et al., 2007. for diagnosis of probable AD.
- Subject with a syndromic presentation of mild cognitive impairment or mild dementia
- Subject has a study partner who is able to provide accurate information about the patient
- Subject affiliated to a social security scheme
Exclusion
- Patient who meets both AD and Lewy Body disease criteria
- Contraindications to lumbar puncture
- Contraindications to an MRI scan
- Subject who is not affiliated to a social security scheme
- Subject under guardianship or curatorship
- Subject under judicial protection
- Subject refuses to participate in the study
- Subject has evidence of clinically relevant neurological disorder (fronto-temporal dementia, brain tumor, stroke, …) that led to persistent cognitive disorders
- Subject has evidence of clinically relevant psychiatric disorders (schizophrenia, major depression, …)
- Pregnant or attempting to become pregnant women
- Subject's vision and audition is sufficient for neuropsychological tests's assessment, based on the investigator's judgment.
Key Trial Info
Start Date :
April 1 2013
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
April 1 2015
Estimated Enrollment :
265 Patients enrolled
Trial Details
Trial ID
NCT01876459
Start Date
April 1 2013
End Date
April 1 2015
Last Update
June 18 2013
Active Locations (1)
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1
Hôpitaux Universitaires de Strasbourg
Strasbourg, Hôpital de Hautepierre, France, 67098