Status:
COMPLETED
Adjunctive Clindamycin for Cellulitis: C4C Trial.
Lead Sponsor:
University Hospitals Bristol and Weston NHS Foundation Trust
Collaborating Sponsors:
University of Bristol
Public Health England
Conditions:
Cellulitis
Eligibility:
All Genders
18+ years
Phase:
PHASE4
Brief Summary
The aim of this study is to see whether the addition of Clindamycin, a protein inhibiting antibiotic, to the standard antibiotic treatment of limb cellulitis, with Flucloxacillin, results in less tiss...
Detailed Description
Criteria to be used to assess tissue damage and clinical response: 1. Fever, tachycardia, neutrophil count, urea and other laboratory parameters at five and ten days post first dose of clindamycin 2....
Eligibility Criteria
Inclusion
- Male or female subjects aged 18 or over who have a diagnosis of cellulitis of a single, upper or lower, limb
- Who are able to understand the study and give consent
- Who are able to take oral medication
Exclusion
- Patients with a confirmed history of penicillin, flucloxacillin or clindamycin allergy
- Patients known to be colonised with Methicillin-resistant Staphylococcus aureus or Methicillin-resistant Staphylococcus aureus isolated from wound within the last year
- Patients unable to take oral medication
- Previous history of Clostridium difficile colitis
- Clindamycin taken within the last 30 days
- Clinically unstable
- Unable to understand the study or give consent
- Any doubt over the certainty of the diagnosis of cellulitis
- Patients taking any drug that is incompatible with either flucloxacillin or clindamycin
- Pre-existing diarrhoea
Key Trial Info
Start Date :
October 1 2013
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
March 1 2016
Estimated Enrollment :
410 Patients enrolled
Trial Details
Trial ID
NCT01876628
Start Date
October 1 2013
End Date
March 1 2016
Last Update
August 17 2022
Active Locations (1)
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1
University Hospitals Bristol NHS Foundation Trust
Bristol, United Kingdom, BS2 8HW