Status:
COMPLETED
HSV Oral Reactivation in Children
Lead Sponsor:
Dartmouth-Hitchcock Medical Center
Conditions:
HSV-1
HIV
Eligibility:
All Genders
3-12 years
Brief Summary
In the proposed study, the investigators will carry out novel research to evaluate both symptomatic and asymptomatic daily oral herpes simplex virus (HSV) shedding rates and copy number in children wi...
Eligibility Criteria
Inclusion
- age \> 3 and ≤12 years old
- parental/guardian consent and children's assent must be obtained and participants and parent/guardian must be able to comply with study procedures
- For HIV-infected group: Positive HIV serology by either ELISA x 2, ELISA + WB or PCR testing
Exclusion
- age \<3 and \> 12 years old
- Acute illness which by opinion of the investigator makes enrollment in the trial unfeasible (including active tuberculosis, malaria or other opportunistic infection requiring treatment)
- co-enrollment in other therapeutic/intervention trials (observational trial enrollment is permitted).
- Stable co-administration of other medications is permitted (e.g. bactrim)
- For HIV-infected children; receiving or eligible for antiretroviral (ART) therapy by local standards
Key Trial Info
Start Date :
September 1 2008
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
Estimated Enrollment :
30 Patients enrolled
Trial Details
Trial ID
NCT01878279
Start Date
September 1 2008
Last Update
June 14 2013
Active Locations (1)
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1
MUHAS
Dar es Salaam, Tanzania