Status:
COMPLETED
Gene Analysis and Treatment Optimization in Chinese Homozygous Familial Hypercholesterolemia
Lead Sponsor:
Central South University
Conditions:
Homozygous Familial Hypercholesterolemia
Eligibility:
All Genders
Brief Summary
Identify new or novel genes which may impact on cholesterol level, and establish the relationship between those gene mutations with atherosclerosis, as well as responses to lipid-lowering drugs.
Detailed Description
To better understand the genetics basis for LDL-C elevation and develop an optimized lipid-lowering strategy, we propose to do the following studies: 1. To establish a China HoFH registry, and collec...
Eligibility Criteria
Inclusion
- Inclusion criteria:
- Patients of any age and sex who meet clinical or genetic criteria for hoFH as follows:
- Cutaneous xanthomata before the age of ten years
- LDLC \> 13 mmol/L before treatment or \> 7.76 mmol/L despite treatment
- Phenotypic features in keeping with HeFH in both parents
- Exclusion criteria:
- Inability of patient, or, if less than 18, a parent, to sign informed consent.
Exclusion
Key Trial Info
Start Date :
October 1 2001
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
January 1 2015
Estimated Enrollment :
5 Patients enrolled
Trial Details
Trial ID
NCT01878604
Start Date
October 1 2001
End Date
January 1 2015
Last Update
February 20 2017
Active Locations (1)
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1
Cardiology department of 2nd Xiangya Hospital
Changsha, Hunan, China, 410011