Status:
ACTIVE_NOT_RECRUITING
Effects of N-acetyl Cysteine During Percutaneous Coronary Intervention
Lead Sponsor:
Suleyman Demirel University
Conditions:
Coronary Artery Disease
Eligibility:
All Genders
18-85 years
Phase:
PHASE3
Brief Summary
The aim of this study is to evaluate the effects of N-acetyl cysteine on periprocedural myocardial infarction and major cardiac and cerebral events in patients undergoing percutaneous coronary interve...
Eligibility Criteria
Inclusion
- Patients \> 18 years old undergoing percutaneous coronary intervention and who have moderate to high risk for contrast induced nephropathy (Mehran Score ≥ 5)
Exclusion
- Primary percutaneous coronary intervention
- Low risk for contrast induced nephropathy (Mehran Score \< 5)
- Use of nephrotoxic agents (NSAIDs, aminoglycosides,recent contrast injection...)
- Infection
- Pregnancy, Lactation
- Renal failure requiring dialysis
- Hepatic failure
- History allergy for NAC
- History of Asthma
- Chronic nitrate usage
- Malignancy
- Use of corticosteroids
- Leukocytosis,Thrombocytosis,Anemia
- Blood pressure of \>180/100mmHg despite anti-hypertensive therapy
Key Trial Info
Start Date :
January 1 2013
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
December 1 2026
Estimated Enrollment :
390 Patients enrolled
Trial Details
Trial ID
NCT01878669
Start Date
January 1 2013
End Date
December 1 2026
Last Update
May 20 2025
Active Locations (1)
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1
Suleyman Demirel University
Isparta, Mediterranean Region, Turkey (Türkiye), 32260