Status:
COMPLETED
Molecular Phenotyping of Asthma in Sickle Cell Disease
Lead Sponsor:
Nemours Children's Clinic
Conditions:
Sickle Cell Disease
Asthma
Eligibility:
All Genders
6-20 years
Brief Summary
Asthma and sickle cell disease each are serious medical problems. People with asthma have difficulty breathing, wheeze (a whistling noise when breathing), cough, produce sputum or phlegm, and have inf...
Detailed Description
Asthma recently has been described as a disorder of multiple subphenotypes despite a common symptom presentation. These subphenotypes have differing molecular pathways and discovering these difference...
Eligibility Criteria
Inclusion
- Patients are aged 6 years old up to 21 years old
- Children with sickle cell disease with the genotype SS, SC, or S β 0 thal
- African American children with asthma who do not have sickle cell disease or sickle cell disease trait.
- African American children with no chronic disease
- Physician diagnosed asthma and atopy (of any asthma severity) plus a family history of asthma 89,90
- Patients whose controller respiratory medications and maintenance medications for sickle cell disease (e.g. hydroxyurea) have been unchanged for the previous 4 weeks
Exclusion
- Patients who are current smokers
- Patients who had an inflammatory event related to sickle cell disease (pain episode, priapism, acute chest syndrome, urgent medical visit), asthma exacerbation, or respiratory infection within 1 month prior to the blood, saliva, and urine collection.
- Patients who are receiving chronic transfusion therapy and who have received a transfusion within 90 days prior to blood, saliva, and urine collection.
- Patients who have received treatment with a leukotriene synthesis inhibitor or a leukotriene modifier\[montelukast (Singulair®)\] within the 2 weeks prior to blood and urine collection.
- Women who are pregnant or lactating
Key Trial Info
Start Date :
June 1 2011
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
February 28 2016
Estimated Enrollment :
99 Patients enrolled
Trial Details
Trial ID
NCT01879592
Start Date
June 1 2011
End Date
February 28 2016
Last Update
March 28 2017
Active Locations (3)
Enter a location and click search to find clinical trials sorted by distance.
1
Nemours Children's Clinic
Wilmington, Delaware, United States, 19803
2
Nemours Children's Clinic
Jacksonville, Florida, United States, 32207
3
Nemours Children's Clinic
Orlando, Florida, United States, 32827