Status:
COMPLETED
A Comparative Study of Volume Replacement With HES 130/0.4 Versus Ringer's Lactate (RL) Regarding Their Effects on Inflammatory Biomarkers (Cytokines and Matrix Metalloproteinases) Responses to Major Abdominal Surgery.
Lead Sponsor:
Paraskevi Matsota
Conditions:
Postoperative Inflammation
Eligibility:
All Genders
18-76 years
Phase:
NA
Brief Summary
Various stimuli such as trauma, infection and major surgery may alter the physiologic immune balance and initiate systemic inflammatory processes. This pathophysiological event is characterized by the...
Eligibility Criteria
Inclusion
- ASA (American Society of Anesthesiologists) I and ASA II
Exclusion
- cardiac insufficiency ( \> New York Heart Association (NYHA) class II)
- renal insufficiency (serum creatinine \> 200μm/L)
- severe pulmonary disease (chronic obstructive lung disease, PaO2 \< 70 mmHg when FiO2= 0.21)
- liver disfunction (AST \> 40 U/L, ALT \> 40 U/L)
- diabetes mellitus
- autoimmune disease
- pre-existing signs of bacterial (WBC \> 10000, body temperature \> 38.0 C)or viral infection (HBV, HCV, HIV, CMV)
- pre-existing signs of active inflammation (CRP \> 4)
- malignant neoplasia
- morbid obesity
- patients in extreme muscular activity (athletes)
- patients with chronic use of corticosteroids or β- blockers or non-steroid anti-inflammatory substances
- known allergic reactions to colloids solutions
Key Trial Info
Start Date :
December 1 2008
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
Estimated Enrollment :
47 Patients enrolled
Trial Details
Trial ID
NCT01880190
Start Date
December 1 2008
Last Update
July 15 2013
Active Locations (1)
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1
2nd Department of Anesthesiology, Attikon University Hospital
Athens, Attica, Greece, 12462