Status:
COMPLETED
Tetracycline as a Prophylaxis for Rash in Patients With NSCLC Receiving Treatment With BIBW2992 (Afatinib)
Lead Sponsor:
Instituto Nacional de Cancerologia de Mexico
Conditions:
Skin Rash
Lung Cancer
Eligibility:
All Genders
18+ years
Phase:
PHASE2
Brief Summary
1. Advanced NSCLC has a poor prognosis and the positive impact of chemotherapy is limited by the development of intrinsic and acquired resistance. 2. Over the past decade, less toxic agents such as th...
Detailed Description
Case reports have tried to demonstrate the benefit in the treatment of rash obtained with: alcohol-free emollients used 2-3 times daily, sunscreen with titanium dioxide or zinc oxide with a skin prote...
Eligibility Criteria
Inclusion
- Diagnosis of non-operable, locally advanced, recurrent or metastatic, histologically or cytologically documented non-small cell lung cancer (stage IIIB or IV).
- Patients should have an evidence of measurable disease.
- 18 years or older
- Eastern Cooperative Oncology Group - Performance Status 0-3
- At least 12 weeks of life expectancy
- Patients with non-small cell lung cancer stages IIIB/IV who have received at least one cycle of platinum-based, first or second line systemic standard chemotherapy, and have a documented failure for this treatment.
- More than 2 previous chemotherapy regimens are not allowed. The patients should have recovered from any toxic effect and at least 2 weeks should have elapsed from last dose before their entry (14 days for vinorelbine and other vinca alkaloids or gemcitabine). Patients who in the investigator's opinion are fully recovered from surgery for at least 4 weeks may also be considered for the study. Patients should have recovered from any severe toxicity (CTC \> 1) caused by any previous therapy.
- Granulocyte count \> 1.5x 109/L and platelet count \> 100x 109/L.
- Serum bilirubin \> 1.5 upper limit of normal (ULN)
- AST and/or ALT \> 2 ULN (or \>5 x ULN when clearly attributable to presence of hepatic metastases).
- Serum creatinine \> 1.5 ULN or creatinine clearance \< 60 mL/min
- Capability to fulfill the study and follow-up procedures.
- A negative pregnancy test should be obtained from all women of childbearing potential within 72 hours previous to therapy beginning.
- Patients of reproductive potential should use effective contraceptive methods.
- Written (signed) informed consent to participate in the study
Exclusion
- Patients allergic to the antibiotic therapy used.
- Any unsteady systemic disease (including active infection, uncontrolled hypertension, unsteady angina, congestive cardiac failure, hepatic, renal or metabolic disease).
- A previous treatment using a systemic anti-tumor therapy with EGFR inhibitors (tyrosine kinase inhibitors).
- Any other malignant pathology within 5 previous years (except for carcinoma in situ of cervix or basal-cell type skin cancer appropriately treated).
- Patients with cerebral metastases or spinal marrow compression recently diagnosed and/or definitely surgery and/or radiation naïve-treatment patients are excluded. Those with previously diagnosed and treated metastasis to Central Nervous System (CNS) or spinal marrow compression, having an evidence of steady disease (clinically steady in imaging studies) are accepted for at least 2 months.
- Any significant ophthalmologic abnormality, especially severe dry-eye syndrome, keratoconjunctivitis sicca, Sjögren's syndrome, severe exposure keratitis and any other disorder that may increase the risk for corneal epithelial injure. Contact lens use during the study is not recommended. The decision to continue to use contact lens should be discussed with the oncologist responsible for patient treatment and the ophthalmologist.
- Patients who cannot take oral medication, requiring intravenous nutrition, who underwent previous surgical procedures affecting absorption, or with active peptic ulcer.
- Nursing women.
Key Trial Info
Start Date :
December 1 2010
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
November 1 2014
Estimated Enrollment :
107 Patients enrolled
Trial Details
Trial ID
NCT01880515
Start Date
December 1 2010
End Date
November 1 2014
Last Update
May 11 2025
Active Locations (1)
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1
Instituto Nacional de Cancerología
Mexico City, Mexico, 14080