Status:
COMPLETED
Reoxygenation After Cardiac Arrest (REOX Study)
Lead Sponsor:
The Cooper Health System
Collaborating Sponsors:
National Heart, Lung, and Blood Institute (NHLBI)
Conditions:
Cardiac Arrest
Eligibility:
All Genders
18+ years
Brief Summary
The broad objective of this study is to test the association between hyperoxia exposure after resuscitation from cardiac arrest and outcome. Our overarching hypothesis is that hyperoxia after ROSC is ...
Detailed Description
Specific Aim 1: Test if the degree and duration of hyperoxia following ROSC from cardiac arrest is associated with the degree of in vivo oxidative stress during the post-resuscitation phase of therapy...
Eligibility Criteria
Inclusion
- Age \>17 years
- Cardiac arrest
- Return of spontaneous circulation
- Not following commands immediately after ROSC
- Endotracheal intubation
- Clinician intent to treat with therapeutic hypothermia (or absence of clinician intent to withhold therapeutic hypothermia)
Exclusion
- Presumed etiology of arrest is trauma
- Presumed etiology of arrest is hemorrhage
- Presumed etiology of arrest is sepsis
- Permanent resident of nursing home or other long-term care facility
- Any other condition, that in the opinion of the investigator, would preclude the subject from being a suitable candidate, e.g. end stage chronic illness with no reasonable expectation of survival to hospital discharge
Key Trial Info
Start Date :
June 1 2013
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
June 1 2017
Estimated Enrollment :
280 Patients enrolled
Trial Details
Trial ID
NCT01881243
Start Date
June 1 2013
End Date
June 1 2017
Last Update
November 25 2019
Active Locations (5)
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1
Indiana University/ Methodist Hospital
Indianapolis, Indiana, United States, 46202
2
Beth Israel Deaconess Medical Center
Boston, Massachusetts, United States, 02215
3
University of Mississippi Medical Center
Jackson, Mississippi, United States, 39216
4
Cooper University Hospital
Camden, New Jersey, United States, 08103