Status:
COMPLETED
The ImageKids Study: Developing the pMEDIC and the PICMI
Lead Sponsor:
Shaare Zedek Medical Center
Collaborating Sponsors:
Children's Hospital of Eastern Ontario
McMaster Children's Hospital
Conditions:
Crohn's Disease
Eligibility:
All Genders
5-18 years
Phase:
NA
Brief Summary
The overall objectives of this study are to develop two indices capable of measuring intestinal damage, and, separately, inflammatory disease activity in Pediatric Crohn's disease by means of Magnetic...
Detailed Description
The PICMI Score and the pMEDIC are aimed to be discriminative (at one point in time), evaluative (measuring damage progression over time) and predictive. The indices will be used as endpoint measures ...
Eligibility Criteria
Inclusion
- Children (under 18 years of age) with established diagnosis of CD involving any location by the presence of accepted clinical, radiologic, endoscopic and histologic criteria (33, 34).
- Enrolment at the time of performing ileocolonoscopy and esophageal-gastroduodenoscopy (EGD) as part of clinical care for any reason.
- Children will be enrolled at any phase of the disease (at diagnosis and thereafter as required clinically). In order to ensure enough subjects with intestinal damage and since damage is progressing over time, enrolment will be stratified based on disease duration. Enrolment for each stratum of disease duration will be closed after reaching the expected sample size.
- 20% of enrolled children will be within 3 months of diagnosis.
- 20% of children will be between 3 months and 2 years.
- 20% will be 2.01 to 3 years
- 40% will have disease duration over 3-years.
- Children may be enrolled in any disease activity state (PCDAI 0-100).
Exclusion
- Young children requiring anesthesia for lack of cooperation will be excluded (since the enteric contrast cannot be administered during the 2 hours before anesthesia and it is crucial that the contrast be given just prior the test).
- For the first 120 children only, subjects not expected to be available for 18 month follow-up, will be excluded (the last 120 subjects may be enrolled as they are not followed longitudinally).
Key Trial Info
Start Date :
January 1 2013
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
March 1 2017
Estimated Enrollment :
240 Patients enrolled
Trial Details
Trial ID
NCT01881490
Start Date
January 1 2013
End Date
March 1 2017
Last Update
May 1 2017
Active Locations (1)
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1
Shaare Zedek Medical Center
Jerusalem, Israel