Status:
TERMINATED
Non-opioid Analgesic Combination With Morphine for Postoperative Analgesia.
Lead Sponsor:
Rennes University Hospital
Conditions:
Post Operative Analgesia
Eligibility:
All Genders
18+ years
Phase:
PHASE4
Brief Summary
The combination of different analgesic drugs and/or analgesia techniques is part of the standard management of postoperative analgesia. The analysis of the literature reveals a lack of comparison of t...
Detailed Description
Since the description of the concept of balanced analgesia in the early 90's, the combination of different analgesic drugs and/or analgesia techniques is part of the standard management of postoperati...
Eligibility Criteria
Inclusion
- Adults older than 18 years
- Receiving scheduled surgery requiring the use of a PCA to treat postoperative pain
- Patients with a written informed consent
- Patients with a written informed consent for the sub-study on hyperalgesia (patients in the centers concerned)
- Affiliate to a social security system
Exclusion
- Allergy to morphine, paracetamol, nefopam or ketoprofen or to any of their excipients
- Absorption of morphine and / or NOA within 24 hours before surgery
- Absorption of methadone within 48 hours before surgery
- History of epilepsy
- Renal insufficiency (creatinin clearance \<30 ml / min MDRD)
- Hepatic insufficiency
- Severe respiratory insufficiency
- Pregnancy or breastfeeding women
- History of seizures
- Symptomatic urethroprostatic disorders
- Angle-closure glaucoma
- Gastrointestinal, cerebrovascular or other evolving bleedings
- Active peptic ulcer or active gastritis
- Severe heart failure
- History of asthma triggered by taking ketoprofen or similar substances
- Disable adult person under guardianship
- Use of nitrous oxide during anesthesia protocol
Key Trial Info
Start Date :
July 23 2013
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
January 16 2016
Estimated Enrollment :
223 Patients enrolled
Trial Details
Trial ID
NCT01882530
Start Date
July 23 2013
End Date
January 16 2016
Last Update
February 6 2018
Active Locations (19)
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1
Karine Nouette-Gaulain
Bordeaux, France
2
Marcel Chauvin
Boulogne, France
3
Hawa Keita-Meyer
Colombes, France
4
Dominique Fletcher
Garches, France