Status:
COMPLETED
Walnut Consumption, Endothelial Function, and Biomarkers
Lead Sponsor:
Brigham and Women's Hospital
Conditions:
Coronary Heart Disease
Type 2 Diabetes
Eligibility:
All Genders
30+ years
Phase:
NA
Brief Summary
This study will examine whether a twelve-week intervention with one ounce (28 g) per day of walnuts improves endothelial function measured non-invasively using finger probe (EndoPat-2000) in people wi...
Eligibility Criteria
Inclusion
- Age 30+ years
- Prevalent coronary artery disease
- Prevalent type 2 diabetes
Exclusion
- Current eating disorder
- Pregnant or lactating women
- Allergy to walnuts or other nuts
- Inability to provide informed consent or blood samples
- History or prevalent diagnosis of cancer, asthma, kidney insufficiency, stroke, seizures, allergic disorders, or congestive heart failure
- Diagnosis of coronary heart disease or diabetes \< 1 year prior to enrollment
- Intention to move out of greater Boston area within one year
- Current use of walnuts for more than 2 ounces per day
- Bleeding disorder
- Treatment with blood thinning drugs (i.e. warfarin, clopidogrel)
- Major surgical operation 3 months before or after screening
- Organ transplantation
- Current participation in another trial or plan to do so during the study
- Use of vasodilators such as nitroglycerin
- Inability to give informed consent
- Inability to travel to the study center at Brigham and Women's Hospital
Key Trial Info
Start Date :
June 1 2013
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
September 1 2015
Estimated Enrollment :
26 Patients enrolled
Trial Details
Trial ID
NCT01884363
Start Date
June 1 2013
End Date
September 1 2015
Last Update
March 18 2016
Active Locations (1)
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1
Brigham and Women's Hospital
Boston, Massachusetts, United States, 02120