Status:
COMPLETED
N-acetylcysteine (NAC) for Improving Cognitive Dysfunction in Schizophrenia
Lead Sponsor:
VA Greater Los Angeles Healthcare System
Collaborating Sponsors:
VISN 22 Mental Illness Research, Education, and Clinical Center
American Psychiatric Foundation
Conditions:
Schizophrenia
Eligibility:
All Genders
18-65 years
Phase:
PHASE1
Brief Summary
This study will evaluate the effect of the dietary supplement N-acetylcysteine (NAC) on electrophysiologic (EEG) markers related to cognition, as well as performance on psychological tests measuring c...
Detailed Description
Schizophrenia is a serious mental illness associated with substantial social and occupational dysfunction. While positive psychotic symptoms of schizophrenia often respond to antipsychotic medications...
Eligibility Criteria
Inclusion
- Meets DSM-IV-TR criteria for schizophrenia.
- At least 3 months since any psychiatric hospitalization
- At least 1 month since meeting criteria for having a major depressive episode
- At least 6 months since any behaviors suggesting any potential danger to self or others
- Currently prescribed an antipsychotic medication, with dose not varying \>50% over 3 months prior to study participation
- No acute medical problems that could interfere with study participation
- Chronic medical problems consistently treated and stable for at least 3 months prior to participation
- Ability to provide informed consent and cooperate with study procedures
Exclusion
- Documented history of IQ less than 70 or severe learning disability
- History of treatment with electroconvulsive therapy within 6 months prior to study participation
- History of neurological or neuropsychiatric condition (e.g., stroke, severe traumatic brain injury, epilepsy, etc.) that could confound assessments
- Documented history of persistent substance abuse or dependence within 3 months prior to study participation
Key Trial Info
Start Date :
June 1 2013
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
May 1 2014
Estimated Enrollment :
26 Patients enrolled
Trial Details
Trial ID
NCT01885338
Start Date
June 1 2013
End Date
May 1 2014
Last Update
June 4 2015
Active Locations (1)
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1
VA West Los Angeles Healthcare Center
Los Angeles, California, United States, 90073