Status:
UNKNOWN
Repetitive Transcranial Magnetic Stimulation for Apathy Treatment in Alzheimer's Disease
Lead Sponsor:
Federal University of Minas Gerais
Conditions:
Alzheimer's Disease
Apathy
Eligibility:
All Genders
60-85 years
Phase:
PHASE2
Brief Summary
We aim to evaluate the safety and efficacy of repetitive transcranial magnetic stimulation (rTMS) for apathy treatment in patients with Alzheimer's disease (AD). We hypothesize that rTMS will be super...
Detailed Description
This study aims to enroll 40 patients with mild and moderate Alzheimer's disease with apathy symptoms that will be randomized to receive rTMS or sham procedure. Subjects will be randomized in two arms...
Eligibility Criteria
Inclusion
- Age between 60 to 85 years-old
- Mild or moderate Alzheimer's disease (MMSE scores between 10 and 20)
- Apathy diagnosis
- On stable doses of cholinesterase inhibitors (donepezil, galantamine, rivastigmine) and/or memantine for at least 6 months prior to enrollment
Exclusion
- history of epilepsy or convulsions
- History of migraine or headaches episodes twice per week or more
- History of neurodegenerative diseases other than Alzheimer's disease
- Current use of first generation antipsychotics, clozapine, tricyclic drugs or anticonvulsants
- History of cerebral ischemic episode
Key Trial Info
Start Date :
June 1 2013
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
December 1 2015
Estimated Enrollment :
40 Patients enrolled
Trial Details
Trial ID
NCT01885806
Start Date
June 1 2013
End Date
December 1 2015
Last Update
June 25 2013
Active Locations (2)
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1
Federal University of Minas Gerais
Belo Horizonte, Outside of U.S., Brazil, 30130-100
2
Federal University of Minas Gerais
Belo Horizonte, Outside of U.S., Brazil, 30130-100