Status:
TERMINATED
Motor Control During Rapid Eye Movement (REM) Sleep Behaviour Disorder
Lead Sponsor:
University Hospital, Toulouse
Collaborating Sponsors:
Grenoble Institut des Neurosciences
Conditions:
Parkinson Disease
Eligibility:
All Genders
35-70 years
Phase:
NA
Brief Summary
To compare the electrical activity of SubThalamic Nuclei (STN), by mean of local field potentials recordings, during the phasic behaviours of RBD with the electrical activity recorded at this level du...
Detailed Description
Patient with severe Parkinson's disease (PD) with motor fluctuations are akinetic and bradykinetic during the "off" phases. Their motor status dramatically improves during "on" phases, due to the effe...
Eligibility Criteria
Inclusion
- Men and women, 35 to 70 years old, with idiopathic PD (UKPDSBB criteria) with motor fluctuations
- having RBD according to the International Classification of Sleep Disorders, 2nd edition (ICSD-2) criteria
- Eligible to neurosurgical treatment of PD by implantation of intracranial electrodes for the DBS of STN
- Giving a written informed consent
- Affiliated to the French social security program
Exclusion
- Atypical or secondary parkinsonian syndrome
- Cognitive impairment which may compromise the understanding and patient's participation to the protocol (Mattis dementia rating scale score ≥ 136)
- Patient under guardianship, trusteeship or judicial protection
- Pregnancy or breastfeeding
- Patient participating to another clinical research study in the same period
Key Trial Info
Start Date :
June 1 2013
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
July 1 2014
Estimated Enrollment :
3 Patients enrolled
Trial Details
Trial ID
NCT01886131
Start Date
June 1 2013
End Date
July 1 2014
Last Update
February 23 2017
Active Locations (2)
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1
University Hospital of Purpan
Toulouse, Midi-Pyrénées, France, 31059
2
University Hospital of Rangueil
Toulouse, Midi-Pyrénées, France, 31059