Status:
WITHDRAWN
Influence of tDCS on Cortical Plasticity in Patients With Dementia of the Alzheimer Type
Lead Sponsor:
Charite University, Berlin, Germany
Conditions:
Dementia of Type Alzheimer
Eligibility:
All Genders
50-80 years
Phase:
NA
Brief Summary
The aim of this study is to investigate whether the anodal transcranial direct current stimulation (tDCS) over the primary motor cortex (M1) in patients with dementia of the Alzheimer type (DAT) leads...
Eligibility Criteria
Inclusion
- Inclusion Criteria:
- Right-handed according to the Oldfield Händigkeits inventory (lateralization index\> 70) (1971)
- Cognitive impairment, which corresponds to a mild to moderate DAT
- No treatment with AChE inhibitors, or existing stable treatment with AChE inhibitors for over 3 months
- No motor impairments relevant to everyday life
- Age 50 to 80 years
- Existing Insurance certificate
- Existing informed consent
- Exclusion criteria:
- Severe neurological / psychiatric or pre-existing internist conditions because additional cognitive deficits are expected
- Epilepsy, epileptic seizure in medical history
- Cognitive deficit (MMSE \<20)
- Depressive episode (Beck Depression Inventory (BDI)\> 12)
- intake of centrally active drugs \<3 months, particularly acetylcholinesterase inhibitors
- Pregnancy
- Pacemaker (contraindication for MRI)
- Other metal parts in the body (contraindication for MRI)
Exclusion
Key Trial Info
Start Date :
May 1 2013
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
December 1 2017
Estimated Enrollment :
Patients enrolled
Trial Details
Trial ID
NCT01887899
Start Date
May 1 2013
End Date
December 1 2017
Last Update
May 14 2021
Active Locations (1)
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1
Klinik und Poliklinik für Neurologie, Charité Universitätsmedizin Berlin
Berlin, Germany, 10117