Status:
COMPLETED
The Neural Mechanisms of Anesthesia and Human Consciousness
Lead Sponsor:
University of Turku
Collaborating Sponsors:
Academy of Finland
Hospital District of Southwestern Finland
Conditions:
Consciousness, Level Altered
Eligibility:
MALE
20-30 years
Phase:
PHASE4
Brief Summary
The explanation of consciousness poses one of the greatest challenges to science and philosophy in the 21st century. It remains unclear what consciousness is and how it emerges from brain activity. By...
Detailed Description
(not needed)
Eligibility Criteria
Inclusion
- Male
- Age 20-30 years
- Good general health i.e. American Society of Anesthesiologists (ASA) physical status I
- Fluent in Finnish language
- Right handedness
- Written informed consent
- Good sleep quality
Exclusion
- Chronic medication
- History of alcohol and/or drug abuse
- Strong susceptibility for allergic reactions
- Serious nausea in connection with previous anesthesia
- Strong susceptibility for nausea
- Any use of drugs or alcohol during the 48 hours preceding anesthesia
- Use of caffeine products 10-12 hours prior the study, 24 hours before sleep studies
- Smoking
- Clinically significant previous cardiac arrhythmia / cardiac conduction impairment
- Clinically significant abnormality in prestudy laboratory tests
- Positive result in the drug screening test
- Blood donation within 90 days prior to the study
- Participation in any medical study with an experimental drug or device during the preceding 60 days
- The study subject has undergone a prior PET or SPECT study
- Any contraindication to magnetic resonance imaging (MRI)
- Hearing impairment
- Detected unsuitability based on initial electrophysiological measurements
- Detected unsuitability based on MRI scanning results
- Sleep disorder or severe sleep problem
Key Trial Info
Start Date :
February 1 2014
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
January 1 2016
Estimated Enrollment :
47 Patients enrolled
Trial Details
Trial ID
NCT01889004
Start Date
February 1 2014
End Date
January 1 2016
Last Update
January 11 2016
Active Locations (1)
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1
Turku PET Centre
Turku, Finland, FI-20521